Development of Novel Microfluidics Device to Enable Live Cell Imaging

Acted as Lead Engineer on a collaborative project with Bucknell University and Geisinger Department of Cardiac Surgery to develop a novel microfluidic device capable of accurately emulating arterial conditions.

Project responsibilities included:

• Utilizing skills in OnShape CAD software to model different device flow chamber and COMSOL Multiphysics model flow patterns, turbulence, and shear stresses

• 3D printing of functional prototypes to do low-cost design testing and iteration

• Developing part drawings in accordance with ASME Y 14.5 to order manufactured parts

• Culturing and maintaining cell lines and running cellular experiments to ensure device functionality

• Development of device software to convert device inputs to shear stresses within the chamber

• Using ImageJ to quantify cellular alignment in device

• Collaboration with surgeons, machinists, and other researchers to guide project from conception to manufactured final design

Skills Utilized: OnShape CAD Software, COMSOL Multiphysics, Python, Manufacturing, Rapid Prototyping, 3D Printing, Cell Culture, Technical Writing, Communication

Project Outcomes: First-author conference presentation at the BMES (Biomedical Engineering Society) 2023 Annual Meeting in Seattle, 2024 ISTU Meeting in Taipei, Taiwan

Device Images Deliberately Omitted to Protect Intellectual Property During Patent Process